A quiet yet monumental development has happened, and it occurred, back on January 8th 2016 on the National Cancer Institute’s (NCI)website, were there is what would appear to be, a preliminary study or should I say a compilation of research on cannabinoids effects of reducing the growth in certain types of cancer cells. Could this be the break we have all been waiting to see happen is a change to the Controlled Substances Act closer than we think. See the text below as it was taken from the NCI website.
Almost as if to mock the American people the United States Government posts the information to one of its own websites citing the possibility that there may be medical uses for Marijuana but still leave its classification unchanged depriving individuals of the benefits whatever they may be, and depriving the medical community the ability to conduct studies on the uses, application and efficacy of Marijuana.
One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors. During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo . In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5-8]
Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9-12] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. For example, these compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats, while they protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.
So I find it hard to understand the governments continued stance on Marijuana especially in light of the recent developments. Some of the uses of Marijuana although promising must be proven in clinical trials as to the effects and the efficacy rate on certain conditions if not for any reason than other than to not give false hope to individuals and to have them not pass on a therapy that would have better results. When it comes to pain management there is more than enough evidence form the community that trials need to begin as it is common knowledge and well documented from the doctors of those substituting Marijuana for Opiates and the effect, if it didn’t work, people wouldn’t be using it to the level they are, as well the statistic correlating the decrease in Opiate use, addiction and overdoses in states that have Medical Marijuana also points to the efficacy in relationship to pain management. Below I have attempted to prove my point by citing the statistical information relating to the decrease in opioid related issues from dependency to deaths in states that have medical Marijuana, again I find it incredibly difficult to get my mind around how we as people have let our government, the people we elect to lead us continue to force feed the diatribe that Marijuana is bad especially since there was no studies done to prove the government’s stance at the time and for that matter when the CSA (controlled substances act) was enacted in the “70’s” there still was no data to back up the claims.
America has a major problem with prescription pain medications like Vicodin and OxyContin. Overdose deaths from these pharmaceutical opioids have approximately tripled since 1991, and every day 46 people die of such overdoses in the United States. However, in the 13 states that passed laws allowing for the use of medical marijuana between 1999 and 2010, 25 percent fewer people die from opioid overdoses annually. “The difference is quite striking,” said study co-author Colleen Barry, a health policy researcher at Johns Hopkins Bloomberg School of Public Health in Baltimore. The shift showed up quite quickly and become visible the year after medical marijuana was accepted in each state, she told Newsweek.
The researchers looked at death rates from opioids between 1999 and 2010 and found that the 13 states that allowed medical marijuana at the time had lower opioid mortality rates–the hypothesis being that patients with chronic pain perhaps switched from the heavy drugs to marijuana, since cannabinoids in marijuana react similarly in the brain. About 60% of all opioid deaths happen among people who have legitimate prescriptions, but abuse is also problematic. “Among people who use opioids illicitly, a relatively high proportion of them also use marijuana,” says study author Dr. Marcus Bachhuber of the Philadelphia VA Medical Center.
Natural.new January 2016
The study compared the number of pharmaceutical-related deaths in 13 states where medical marijuana was legal before 2010 to states where medical marijuana remains illegal. The report discovered that states where medical marijuana is legal have a 25 percent lower rate of opioid-related deaths. In other words, there were approximately 1,729 fewer opioid-related deaths in 2010 in states where patients have access to medical marijuana. (2) Opioids and narcotics are the primary drugs used to treat chronic pain despite their noxious side effects. According to the CDC, approximately 44 people die every day due to prescription drug overdose. In 2012 alone, healthcare providers wrote more than 259 million prescriptions for painkillers. (1)
Cannabis, on the other hand, can help ease pain, has low levels of toxicity and is impossible to overdose on. In addition, there are cannabinoid receptors in some regions of the brain that can even alter chronic pain. (2) Opioid related deaths still increased across the United States when the most recent study was conducted in 2010. However, states with legal marijuana showed a significantly smaller increase in mortality rates involving painkillers. For instance, rather than pop a deadly opioid like OxyContin for chronic pain, patients can ingest medical cannabis to mitigate pain without the harmful side effects More troubling, researchers from the University of Pennsylvania and Johns Hopkins University, who were involved in the study, found that up to 60 percent of all opioid analgesic overdoses occurred in patients who took doses dictated by the prescription.All Articles Site the JAMA-Journal of the America Medical Association
These statistics make the entire argument against legalization mute and when you add in the crime and the other ill effects that the use of Marijuana was to have caused, that have not played out in Washington state or Colorado makes you seriously question where the politicians are getting their information from, since it obviously isn’t from any credible study or source. Let’s not get into how many people are incarcerated every day for possession and has ruined their lives and the people that have been denied the use a viable alternative to opiates. I can emphatically state from my own personal experience having shattered the ball to my hip a little over a year ago, the relief from the pain that marijuana provided was incredible but, I had already known the pain relieving effects of Marijuana from years prior, when I broke three knuckles and a finger in another accident and the doctor set my hand without using any medication at all. These are true facts as I do not want to ever be given an opiate based or derived drug. I also, saw veterans praising the use of Marijuana in place of opiates during an expo in October 2016 Phoenix AZ, where Steven D’Angelo was a keynote speaker talking about how their lives had been torn apart by the use of opiates to relieve the pain of missing limbs and how Marijuana helped them to break the addiction and start to recover the pieces of their lives. I truly admire these men for what they went through and commend them for their courage to speak publicly about the turmoil they went through, as it hopefully will spare others the pain of opiate addiction.In closing a word of wisdom – “Educate yourself on the issues most important to you and your community, and vote, in every election”. What we are seeing of the misinformation that has been given the American people regarding Marijuana is appalling. Remember we elected these people to lead us, and give them access to the vast resources of this wealthy nation, to make informed sound decisions based on fact not on conjecture, so that we as a nation can lead through our example. The example we are leading on this one issue is shameful, when you consider the resources available to us.